GI Health

Since its foundation, Tillotts has been committed to improving care for people with gastrointestinal (GI) diseases. We have over 30 years’ expertise in developing and manufacturing treatments for inflammatory bowel disease (IBD), and we have developed a deep understanding of our customers.

Tillotts Pharma UK strive to be the preferred partner in GI health and are dedicated to improving the lives of people with GI diseases and supporting those who care for them.

Inflammatory Bowel Disease (IBD)

The principal forms of inflammatory bowel disease are ulcerative colitis and Crohn’s disease1. These are chronic inflammatory diseases of the gastrointestinal tract affecting an estimated 487,000 people living in the UK, and 2.5-3 million people across Europe. Patients will typically experience periods of disease relapse and remission with ulcerative colitis mainly affecting the colon, whereas Crohn’s disease can affect any part of the gastrointestinal tract1-3.

A third form of inflammatory bowel disease, microscopic colitis, is characterised by chronic or recurrent watery, non-bloody stools. It is estimated to affect around 119 people per 100,000, although there is substantial geographical variation.1-3

1. Rampton DS. & Shanahan F. Fast Facts: Inflammatory Bowel Disease 5th edition, Health Press Ltd. 2016

2. Pasvol TJ, et al. BMJ Open 2020;10:e036584. doi:10.1136/bmjopen-2019-036584

3. https://https://www.crohnsandcolitis.org.uk/about-crohns-and-colitis. Accessed November 2021

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Ulcerative Colitis (UC)

Ulcerative colitis is a condition that causes inflammation and ulceration of the inner lining of the colon and rectum (the large bowel). Inflammation is the body’s reaction to irritation, injury or infection, and can cause redness, swelling and pain. In ulcerative colitis, ulcers develop on the surface of the bowel lining and these may bleed and produce mucus.

The inflammation usually begins in the rectum and lower colon, but it may affect the entire colon. If ulcerative colitis only affects the rectum, it is called proctitis. 4

 

4. https://crohnsandcolitis.org.uk/about-crohns-and-colitis/publications/ulcerative-colitis?. Accessed November 2021

Crohns Disease (CD)

Crohn’s Disease is a condition that causes inflammation of the digestive system (also known as the gastrointestinal tract or gut). Inflammation is the body’s reaction to injury or irritation, and is usually characterised by redness, swelling and pain.

Crohn’s Disease is one of the two main forms of Inflammatory Bowel Disease (IBD). The other main form of IBD is a condition known as Ulcerative Colitis. Crohn’s Disease is sometimes described as a chronic condition. This means that it is ongoing and life-long, although you may have periods of good health (remission) as well as times when symptoms are more active (relapses or flare-ups). In many people the disease runs a benign course with few flare-ups, while other people may have more severe disease. Crohn’s Disease is not infectious. 5

 

5. https://crohnsandcolitis.org.uk/about-crohns-and-colitis/publications/crohns-disease?. Accessed November 2021

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Microscopic colitis

Microscopic Colitis is an Inflammatory Bowel Disease (IBD) that affects the large bowel – the colon and rectum. It isn’t always as well-recognised as Crohn’s Disease or Ulcerative Colitis, which are other forms of IBD.

It can take time to get a diagnosis of microscopic colitis and dealing with the symptoms can be challenging. However, many people respond well once diagnosed and appropriately treated.6

 

6. https://crohnsandcolitis.org.uk/about-crohns-and-colitis/publications/microscopic-colitis. Accessed November 2021

Clostridioides difficile infections

Clostridioides difficile, also known as C. difficile or C. diff, is bacteria that can infect the bowel and cause diarrhoea.

The infection most commonly affects people who have recently been treated with antibiotics. It can spread easily to others.

C. diff infections are unpleasant and can sometimes cause serious bowel problems, they can usually be treated effectively once diagnosed.

7. https://www.nhs.uk/conditions/c-difficile/. Accessed November 2021

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NU-01430 November 2021