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Octasa® modified release tablets

Octasa modified-release tablets contain the active ingredient mesalazine, which is an anti-inflammatory medicine. Octasa modified-release tablets act locally to treat and prevent inflammation in the colon, rectum and terminal ileum.

Octasa tablets have a special coating. This coating helps the active ingredient reach the part of your bowel that is inflamed.

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Octasa 400mg modified release tablets

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Octasa 800mg modified release tablets

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Octasa 1600mg modified release tablets

How do Octasa modified-release tablets work?

Octasa modified-release tablets work by helping to get the inflammation in your bowel under control. This means it helps to relieve the symptoms you have when the inflammation flares up.

Taking Octasa modified-release tablets regularly will also help keep the inflammation down and reduce the chances of your symptoms coming back.

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Taking Octasa regularly

When you are feeling well and symptom free it is really important to continue to take your Octasa modified-release tablets as advised by your doctor, nurse or pharmacist, this is because taking Octasa regularly will help to keep you free of inflammation and the symptoms you feel when you are unwell.

How do I Take Octasa modified-release tablets?

Always take Octasa modified-release tablets exactly as your doctor, nurse or pharmacist has told you. You must swallow the tablets whole, preferably with a glass of water.

Octasa 400 mg and Octasa 800 mg modified-release tablets should be taken before meals however Octasa 1600mg modified-release tablets can be taken with or without food.

It’s important that you don’t crush, chew or break the tablets before swallowing. If the coating is broken, the medicine may not reach the part of your bowel where it’s needed. This means Octasa may not work properly.

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Other support

Crohn’s & Colitis UK offer a wide range of information and support for people affected by inflammatory bowel disease. Please click here to visit CCUK’s website.

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Frequently Asked Questions

Do I need to have any specific tests while taking Octasa modified release tablets?

Your doctor may want to check that your liver, kidneys, blood and lungs are working properly before you take Octasa modified release tablets and while you are taking Octasa modified release tablets.

What should I do if I see a tablet in my stools?

What appear to be intact tablets in stools may in fact be partial tablet casings from which some or all of the active ingredient has been released. However, if you observe tablets or tablet shells in the stool repeatedly, you should discuss this with your doctor.

Can I eat and drink normally when I take Octasa modified release tablets?

You can eat and drink normally when taking Octasa modified release tablets.

Can I take Octasa modified release tablets if I am pregnant, breast-feeding or planning to have a baby?

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Octasa modified release tablets.

Can I drive and/or operate machinery when I am taking Octasa modified release tablets?

Octasa modified release tablets are not expected to affect your ability to drive or operate machinery. However, if you are affected in any way, do not drive or operate machinery.

Can I crush or chew my Octasa modified release tablets?

No, you must NOT crush or chew your Octasa modified release tablets before swallowing. You must take your Octasa tablets whole, preferably with some liquid.

How do I take Octasa modified release tablets?

You should take Octasa modified release tablets as your doctor/nurse has told you. Check with your healthcare provider if you are not sure.

You must swallow your Octasa modified release tablets whole, preferably with some liquid. You must not chew, crush or break your Octasa modified release tablets before swallowing.

Octasa 400mg and 800mg tablets should be taken before meals, whereas Octasa 1600mg tablets may be taken at any time.

Make sure you drink enough fluids to stay well hydrated, especially after severe or prolonged episodes of vomiting and/or diarrhoea, high fever or heavy sweating.

Do not take any tablets after the expiry date, which is stated on the outer packaging.

Should I take my Octasa modified release tablets once daily or in divided doses throughout the day?

You should take Octasa modified release tablets as your doctor or nurse has told you. Check with your healthcare provider if you are not sure.

It is important not to break, crush or chew Octasa modified release tablets, this damages the coating so that the tablet becomes ineffective. The tablets must be swallowed whole.

  • Octasa 400mg and 800mg tablets may be taken once daily or in divided doses up to 2.4g (six 400mg tablets or three 800mg tablets). Doses above 2.4g per day should be taken in divided doses.
  • Octasa 1600mg tablets may be taken once daily or in divided doses.

If you are unsure of how best to divide your Octasa modified release tablets dose please discuss with your doctor, nurse or pharmacist.

Why is it recommended to take Octasa 400mg and 800mg modified release tablets before meals?

Octasa 400mg and 800mg should be taken before meals because ingestion of food, especially fatty food, can sometimes delay emptying of stomach contents into the small intestine. This might also delay passage of the tablets through the intestines and delay the benefits of the treatment.

What should I do if I take more Octasa modified release tablets than I am supposed to?

You shouldn’t take a higher dose than your doctor or nurse has prescribed for you.

If you or anyone else has swallowed too many Octasa modified release tablets, or you think a child has swallowed any, contact your nearest hospital casualty department or doctor for advice.

You should take any tablets that you still have with you if possible.

What should I do if I forget to take Octasa modified release tablets?

If you forget to take your Octasa modified release tablets at the right time, take one as soon as you remember, unless it is nearly time to take the next one.
You must not take a double dose to make up for a forgotten dose.

Can I stop taking Octasa modified release tablets?

You must not stop taking Octasa modified release tablets without talking to your doctor first, even if you feel better.

If you have any further questions on the use of Octasa modified release tablets,
ask your doctor, nurse or pharmacist.

How should I store Octasa modified release tablets?

Keep Octasa modified release tablets out of the reach and sight of children.

Do not store above 25°C.

Keep your tablets in the original package to protect them from moisture.

What do Octasa modified release tablets look like?

Octasa modified release tablets are reddish brown, oblong tablets.
The tablets are available in packs in blister strips.

Are Octasa modified release tablets suitable for vegetarians or vegans?

Octasa 400mg and 800mg tablets contain very small quantities of lactose. Lactose is derived from milk, therefore these tablets are suitable for vegetarians. If you are allergic to lactose or follow a vegan lifestyle you may wish to consult your doctor.

No excipients of animal origin are used to manufacture Octasa 1600mg tablets. Therefore, Octasa 1600mg is suitable for vegetarians and vegans.

Report a side effect

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet.
You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.

By reporting side effects, you can help provide more information on the safety of this medicine.

NU-01435 November 2021